Ka Zhang, Ph.D.

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Titles

Associate Professor of infectious diseases

Master's Supervisor

Department of Infectious Diseases, The Third Affiliated Hospital of SunYat-Sen University

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Research Interests

Clinical diagnosis and treatment of infectious diseases, especially hepatitis

The pathogenesis of HBV or HCV infection

Clinical diagnosis and treatment of cirrhosis and cancer of the liver

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Education and Experience

2000-2005 ?Clinical Medicine, the medical school of Zhengzhou University , Zhou Zheng , NanHe Province

2005-2007 ?Master of Medicine, Sun Yat-sen University, The Third Affiliated Hospital, Guangzhou , Guangdong province

2007-2010 ?M.D, Ph.D (medicine ), Sun Yat-sen University, The Third Affiliated Hospital, Guangzhou , Guangdong province

2010-2015 Lecturer of Medicine, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou Guangdong province

2016-To now Associate Professor of Hepatology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou, Guangdong province

2010-2011 Resident, Department of Infectious Diseases(Liver Center), the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong province

2012-2016 Attending Physician, Department of Infectious Diseases(Liver Center), the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong province

2017 ?to now ?Associate Chief Physician, Department of Infectious Diseases(Liver Center), the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong province

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Honors and Awards

My research focuses on treatment of acute-on-chronic liver failure with hepatitis B and exploration of the mechanism of acute-on-chronic HBV liver failure, and the mechanism of liver cirrhosis and liver cancer

1.The National Natural Science Foundation of China, 2016-2018, head of the program.

2.The Medical Scientific Research Foundation of Guangdong Province, 2012-2014, head of the program.

3.The Medical Research Fund of Guangdong Pharmaceutical Association (Grant Nos. 2012GRS01 and 2013GRS06).

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Publications

The main original articles that were published in the past five years as the following:?

1: Zhang K, Cao H, Liang J, Shu X, Sun H, Li G, Xu Q. CONSORT: Effects of adding adefovir dipivoxil to peginterferon alfa-2a at different time points on HBeAg-positive patients: A prospective, randomized study. Medicine (Baltimore). 2016 Aug;95(31):e4471. doi: 10.1097/MD.0000000000004471. PubMed PMID: 27495085;PubMed Central PMCID: PMC4979839.

2: Zhang K, Shu X, Luo HF, Zhu FQ, Cao H, Xu QH, Li G. [ROG,GATA3 and T-bet mRNA ?levels in peripheral blood mononuclear cells in patients with chronic hepatitisB]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):186-9. Chinese. PubMed PMID:26922013.

3: Xiao CH, Sun HX, Zhang K, Pan XF, Huang FF, Xu QH. [Comparative study on the clinical characteristics of HBV infection patients with different pathologic inflammation grade]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2013 Aug;27(4):270-2. Chinese. PubMed PMID: 24579472.

4: Lai J, Sun HX, Jie YS, Zhang K, Ke WM. Serum HBsAg level and its clinical significance in lamivudine treatment for patients with HBeAg-negative acute-on-chronic liver failure. Int J Infect Dis. 2014 May;22:78-82. doi:10.1016/j.ijid.2013.12.018. Epub 2014 Feb 8. PubMed PMID: 24518440.

5: Cao H, Pan XF, Zhang K, Shu X, Li G. [Interleukin-32 expression is induced by ?hepatitis B virus]. Zhonghua Gan Zang Bing Za Zhi. 2013 Jun;21(6):442-5. doi:10.3760/cma.j.issn.1007-3418.2013.06.014. Chinese. PubMed PMID: 24034846.

6: Pan X, Zhang K, Yang X, Liang J, Sun H, Li X, Zou Y, Xu Q, An G, Li G, Xu Q. Relapse rate and associated-factor of recurrence after stopping NUCs therapy with different prolonged consolidation therapy in HBeAg positive CHB patients. PLoS One. 2013 Jul 3;8(7):e68568. doi: 10.1371/journal.pone.0068568. Print 2013. PubMed PMID: 23844222; PubMed Central PMCID: PMC3701059.

7: Zhang K, Pan X, Shu X, Cao H, Chen L, Zou Y, Deng H, Li G, Xu Q. Relationship ?between MIF-173 G/C polymorphism and susceptibility to chronic hepatitis B andHBV-induced liver cirrhosis. Cell Immunol. 2013 Apr;282(2):113-6. doi:10.1016/j.cellimm.2013.04.013. Epub 2013 May 6. PubMed PMID: 23770720.

8: Pan XF, Zhang K, Yang XA, Li XJ, Xu QH. [Interleukin-21 expression in serum of patients with acute-on-chronic liver failure and its significance]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Dec;26(6):477-9. Chinese. PubMed PMID:23627035.

9: Lai J, Gan WQ, Xie DY, Zhang K, Ke WM, Gao ZL. [Dynamics of serum HBV DNA levels during the terminal phases of acute-on-chronic hepatitis B liver failure with different HBeAg status]. Zhonghua Gan Zang Bing Za Zhi. 2012Jul;20(7):522-5. doi: 10.3760/cma.j.issn.1007-3418.2012.07.009. Chinese. PubMed PMID: 23044238.

10: Xu Q, Pan X, Shu X, Cao H, Li X, Zhang K, Lu J, Zou Y, Li X, Liu H, Zhang Y, Yang D, Ning Q, Shen G, Li G. Increased interleukin-32 expression in chronic hepatitis B virus-infected liver. J Infect. 2012 Oct;65(4):336-42. doi:10.1016/j.jinf.2012.05.009. Epub 2012 Jun 8. PubMed PMID: 22687868.

11: Cao H, Zhang K, Shu X, Xu QH, Li G. [Detection of core antigen of hepatitis virus C in patients infected with hepatitis virus C and B]. Zhonghua Gan Zang Bing Za Zhi. 2011 Oct;19(10):726-8. doi: 10.3760/cma.j.issn.1007-3418.2011.10.002. Chinese. PubMed PMID: 22409841.

12: Liang JY, Yang XA, Zhang K, Chen LB, Shu X, Xu QH. [A clinical study on the efficacy of HBeAg-positive chronic hepatitis B patients treated with adefovir dipivoxil for 4 years]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011Oct;25(5):384-6. Chinese. PubMed PMID: 22338232.

13: Cao H, Zhang K, Shu X, Xu QH, Li G. [Detection of hepatitis C core antigen in intravenous drug addictions]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Aug;25(4):304-6. Chinese. PubMed PMID: 22097615.

14: Zhang K, Cao H, Yang XA, Hong XL, Chen LB, Shu X, Li G, Xu QH. [Comparative study on the clinical characteristics of HBV/HCV co-infection patients with different HCV contaminnation mode]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2011 Aug;25(4):301-3. Chinese. PubMed PMID: 22097614.

15: Sun HX, Cao H, Zhang K, Yang XA, Li G, Xu QH. [The levels of HBsAg can predict the efficacy of peglated interferon-alpha 2a combined with adefovir dipivoxil, in HBeAg-positive chronic hepatitis B patients]. Zhonghua Shi Yan HeLin Chuang Bing Du Xue Za Zhi. 2011 Apr;25(2):132-4. Chinese. PubMed PMID: 21863639.

16: Yang XA, Zhang K, Shu X, Cao H, Xu QH. [Adenoviruses mediated BCL-X1 overexpression protects mice from fulminant hepatic failure]. Zhonghua Shi Yan HeLin Chuang Bing Du Xue Za Zhi. 2011 Apr;25(2):109-11. Chinese. PubMed PMID:21863631.

17: Hong XL, Cao H, Zhao F, Pan XF, Zhang K, Xu QH, Zhao ZX, Li G. [MiR-196a-2gene polymorphism and the antiviral therapy of chronic hepatitis C]. Zhonghua ShiYan He Lin Chuang Bing Du Xue Za Zhi. 2010 Dec;24(6):470-2. Chinese. PubMed PMID:21604580.

18: Chen LB, Cao H, Zhang YF, Shu X, Chen N, Zhang K, Li G, Xu QH. [Efficacy ofantiviral treatment on patients with acute-on-chronic hepatitis B liver failurewith low viral load]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010Oct;24(5):364-6. Chinese. PubMed PMID: 21280326.

19: Cao H, Shu X, Chen LB, Zhang K, Xu QH, Li G. [The relationship of expression of BMP-7 in the liver and hepatic inflammation and fibrosis in patients withchronic HBV infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010Apr;24(2):101-3. Chinese. PubMed PMID: 21110425.

20: Jie YS, Chen LB, Shu X, Yang XA, Zhang K, Xu QH, Li G. [The effect ofantiviral therapy for patients with HBeAg-negative cirrhosis]. Zhonghua Shi YanHe Lin Chuang Bing Du Xue Za Zhi. 2010 Feb;24(1):45-7. Chinese. PubMed PMID:20848849.

21: Chen LB, Shu X, Jie YS, Yang XA, Zhang K, Li G, Xu QH. [Short-term efficacyof adefovir dipivoxil as an add-on therapy in the pegylated IFNalpha-2a treatmentfor HBeAg positive chronic hepatitis B patients]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010 Feb;24(1):39-41. Chinese. PubMed PMID: 20848847.

22: Xu QH, Chen LB, Xu Z, Shu X, Chen N, Cao H, Zhang K, Li G. [The short-termefficacy of antiviral treatment in patients with acute-on-chronic hepatitis Bliver failure]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009Dec;23(6):467-9. Chinese. PubMed PMID: 20718359.

23: Wei ZW, Xu QH, Shu X, Jie YS, Zhang K, Xie QF, Li G. [The antiviral treatmentimpacts on clinical outcomes of renal transplantation recipients with hepatitis Bvirus infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009Jun;23(3):224-6. Chinese. PubMed PMID: 20104785.

24: Xu QH, Shu X, Chen LB, Zhang K, Li G. [Comparison of clinical features frompatients with chronic hepatitis B between HBeAg negative and positive]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009 Jun;23(3):211-3. Chinese. PubMedPMID: 20104781.

25: Zhang K, Xu QH, Chen LB, Shu X, Chen N, Li G. [Correlation of serum chemokineRANTES level with serum biochemical indices, HBeAg and HBV DNA load in patientswith chronic hepatitis B]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi.2009 Jun;23(3):188-90. Chinese. PubMed PMID: 20104774.

26: Chen LB, Huang HH, Shu X, Xu QH, Chen N, Zhang K, Li G. [Pathological studyof liver biopsy from 156 patients clinically diagnosed with mild chronichepatitis B based on current guideline]. Zhonghua Shi Yan He Lin Chuang Bing DuXue Za Zhi. 2009 Apr;23(2):138-40. Chinese. PubMed PMID: 20104760.

27: Shu X, Xu QH, Chen N, Zhang K, Li G. [The clinic features and the short-term efficacy of entecavir treatment of the HBeAG negative acute-on-chronic hepatitis B liver failure]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008Dec;22(6):481-3. Chinese. PubMed PMID: 19544652.

28: Xu QH, Shu X, Chen LB, Huang HH, Zhang K, Li G. [Relationships between liver function test, serum HBeAg or HBV DNA level and liver pathological changes inpatients with chronic hepatitis B]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue ZaZhi. 2008 Dec;22(6):422-4. Chinese. PubMed PMID: 19544633.

29: Zhang K, Xu QH, Chen LB, Shu X, Cao H, Li G. [The measurement andsignificance of serum chemokine RANTES in patients with chronic hepatitis B].Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Aug;22(4):293-5. Chinese.PubMed PMID: 19105348.

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Contact

Department of Infectious Disease

The Third Affiliated Hospital of the Sun Yat-sen University

No 600# Tianhe Road, Guangzhou, 510630, P. R. China

Appointment Phone: +86 020-85252372

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