Guoying Wang, MD, PhD

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Title

Associate Professor of Surgery

Department of Hepatobiliry Surgery and Liver Transplantation of the Third Affiliated Hospital of Sun Yat-Sen University

Research Interests

• Liver ischemia/reperfusion injury

• Liver regeneration and carcinogenesis

• Immune tolerance

• Liver transplantation

• Multivisceral Transplantation

His principal research interests are the induction of immune tolerance in organ transplantation, the immune regulation role of mesenchymal stem cells, the optimal immunosuppressive therapy, protection from hepatic ischemia/reperfusion injury, and mechanisms associated with carcinogenesis of hepatocellular carcinoma. His honors included the Young Investigator Award in the 17th and 22nd Annual International Congress of the International Liver Transplantation Society (ILTS), the Travel Award in the 12th Congress of the Asian Society of Transplantation, the Young Innovator Award in the 3rd Annual Scientific Exchange of the American Society of Transplantation, and the Young Innovator Award in the EASL Special Conference on Liver Transplantation 2011. He has received funding from the National Natural Science Foundation of China and the others. Dr. Wang is one of candidates of the “Thousand-Hundred-Ten Talent Training Program” of Guangdong Province, and the “Outstanding Young Talents Program” of the Third Affiliated Hospital of Sun Yat-Sen University. He is a member of the editorial board of the journal of Translational Cancer Research, World Journal of Hepatology, Organ Transplantation. He is also the invited reviewer for several international journals, such as Hepatology、Tumor Biology、Plos One、Medical Science Monitor.

Dr. Wang’s other research interests include early non-invasive diagnosis of allograft rejection, and surgical management of portal hypertension.

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Education and Experience

MD, Anhui Medical University

PhD, Sun Yat-Sen University

Post-doctor Fellow, Indiana University-Purdue University Indianapolis

Residency, First Affiliated Hospital of Anhui Medical University

Fellowship, Third Affiliated Hospital of Sun Yat-Sen University

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Honors and Awards

International Liver Transplantation Society – Young Investigator Award, 2011

Asian Society of Transplantation – Travel Award, 2011

American Society of Transplantation – Young Innovator Award, 2011

European Association for the Study of the Liver – Young Innovator Award, 2011

The first prize for outstanding scientific paper in Guangzhou development zone, 2012

International Liver Transplantation Society – Young Investigator Award, 2016

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Publications

1.Guoying Wang, Nan Jiang, Hui-Min Yi, Gen-Shu Wang, Jian-Wen Zhang, Hua Li, Jian Zhang, Qi Zhang, Yang Yang, Gui-Hua Chen. Pretransplant elevated plasma fibrinogen level is a novel prognostic predictor for hepatocellular carcinoma recurrence and patient survival following liver transplantation. Annals of Transplantation. 2016;21:125-30.

2.Nan Jiang, Wenjie Chen, Jianwen Zhang, Chi Xu, Xiancheng Zeng, Tong Zhang, Yang Li, Guoying Wang (corresponding author). Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation. Oncotarget. 2015;6(10):7866-79.

3.Yong Zou, Junjie Bao, Xingfei Pan, Ying Lu, Sihong Liao, Xicheng Wang, Guoying Wang (co-corresponding author), Dongjun Lin. NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure. PLoS One. 2015;10(8):e0134568.

4.Guo-Ying Wang, Yang Yang, Hua Li, Jian Zhang, Nan Jiang, Min-Ru Li, Huan-Bing Zhu, Qi Zhang, Gui-Hua Chen.?A scoring model based on?neutrophil to lymphocyte ratio predicts recurrence of HBV-associated?hepatocellular carcinoma?after liver transplantation. PLoS One. 2011; 6(9):e25295.

5.Guo-Ying Wang, Gui-Hua Chen, Hua Li, Yong Huang, Gen-Shu Wang, Nan Jiang and Bin-Sheng Fu. Rapamycin-treated mature dendritic cells have a unique cytokine secretion profile and impaired allostimulatory capacity. Transplant International. 2009; 22(10):1005-1016.

6.Guo-Ying Wang, Yang Yang, Hua Li, Jian Zhang, Min-Ru Li, Qi Zhang, Gui-Hua Chen. Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4+CD25+Foxp3+ regulatory T cells expansion. Hepatology Research. 2012; 2(2):192-202.

7.Guo-Ying Wang, Qi Zhang, Yang Yang, Wen-Jie Chen, Wei Liu, Nan Jiang, Gui-Hua Chen. Rapamycin combined with allogenic immature dendritic cells selectively expands CD4+CD25+Foxp3+ regulatory T cells in rats. Hepatobiliary Pancreat Dis Int. 2012;11(2): 203-208.

8.Guo-Ying Wang, Gui-Hua Chen, Hua Li, Yong Huang, Jian Zhang, Nan Jiang, Wei-Jin Chen. Rapamycin Inhibits Activator Protein 1 But Not Nuclear Factor κB Activity of Mature Bone Marrow Derived Dendritic Cells. Transplantation proceedings. 2010; 42(6):1881-1883.

9.Guo-Ying Wang, Hua Li, Wei Liu, Jian Zhang, Huan-Bing Zhu, Gen-Shu Wang, Qi Zhang, Yang Yang, Gui-Hua Chen. Elevated blood eosinophil count is a valuable biomarker for predicting late acute cellular rejection after liver transplantation. Transplantation proceedings. 2013;45(3):1198-1200.

10.Yinan Deng, Shuhong Yi, Guoying Wang(co-first author), Jintao Cheng, Yingcai Zhang, Wenjie Chen, Yan Tai, Shaohong Chen, Guihua Chen, Wei Liu, Qi Zhang, Yang Yang. Umbilical Cord-Derived Mesenchymal Stem Cells Instruct Dendritic Cells to Acquire Tolerogenic Phenotypes through the IL-6-Mediated Upregulation of SOCS1. Stem Cells and Development. 2014; 23(17): 2080-2091.

11.De-Hao Huang, Guo-Ying Wang, Jan-Wen Zhang, Yang Li, Xian-Cheng Zeng, Nan Jiang. MiR-501-5p regulates CYLD expression and promotes cell proliferation in human hepatocellular carcinoma. Jpn J Clin Oncol. 2015; 45(8):738-44.

12.Jin-Tao Cheng, Yi-Nan Deng, Hui-Min Yi, Guo-Ying Wang, Bin-Sheng Fu, Wen-Jie Chen, Wei Liu, Yan Tai, Yan-Wen Peng, Qi Zhang. Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation. Oncogenesis. 2016; 22;5:e198.

13.Yang Li, Dan-Yun Ruan, Hui-Min Yi, Guo-Ying Wang, Yang Yang, Nan Jiang. A three-factor preoperative scoring model predicts risk of recurrence after liver resection or transplantation in hepatocellular carcinoma patients with preserved liver function. Hepatobiliary Pancreat Dis Int. 2015; 14(5):477-484.

14.Xian-Cheng Zeng, Liu FQ, Yan R, Hui-Min Yi, Tong Zhang, Guo-Ying Wang, Li Y, Jiang N. Downregulation of miR-610 promotes proliferation and tumorigenicity and activates Wnt/β-catenin signaling in human hepatocellular carcinoma. Mol Cancer. 2014;13(1):261.

15.Gui-Hua Chen, Guo-Ying Wang, Yang Yang, Hua Li, Min-Qiang Lu, Chang-Jie Cai, Gen-Shu Wang, Chi Xu, Shu-Hong Yi, Jun-Feng Zhang, Bin-Sheng Fu. Single-Center Experience of Therapeutic Management of Hepatic Artery Stenosis after Orthotopic Liver Transplantation. Report of 20 Cases. Eur Surg Res. 2009; 42(1):21-27.

16.Li H, Wang S, Wang G, Zhang Z, Wu X, Zhang T, Fu B, Chen G. Yes-Associated Protein Expression is a Predictive Marker for Recurrence of Hepatocellular Carcinoma after Liver Transplantation. DIGESTIVE SURGERY, 2014,31(6):468-478.

17.Tuan-Jie Li, Shu-Hong Yi, Wei Liu, Chang-Chang Jia, Guo-Ying Wang, Xue-Feng Hua, Yan Tai, Qi Zhang, Gui-Hua Chen. Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity. Med Oncol. 2013;30(3):663.

18.Xian-Cheng Zeng, Tong Zhang, De-Hao Huang, Guo-Ying Wang, Wei Chen, Hua Li, Jian Zhang, Tian-Ling Fang, Qi Zhang, Gui-Hua Chen. RNA Interfering Targeting Human Leukocyte Antigen-G Enhanced Immune Surveillance Mediated by the Natural Killer Cells on Hepatocellular Carcinoma. Ann Clin Lab Sci. 2013; 43(2):135-44.

19.Hua Li, Ji-Wen He, Bin-Sheng Fu, Kun Wang, Nan Jiang, Guo-Ying Wang, Jian Zhang, Gen-Shu Wang, Yang Yang, Gui-Hua Chen. Immunosuppressant-Related Hip Pain After Orthotopic Liver Transplant. Exp Clin Transplant. 2013; 11(1):32-8.

20.Hua Li, Jian Zhang, Ji-Wen He, Kun Wang, Gen-Shu Wang, Nan Jiang, Bin-Sheng Fu, Guo-Ying Wang, Yang Yang, Gui-Hua Chen. Symptomatic osteonecrosis of the femoral head after adult orthotopic liver transplantation. Chin Med J (Engl). 2012; 125(14):2422-2426.

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Contact

Third Affiliated Hospital of Sun Yat-Sen University

600. TianHe Road, TianHe District

GuangZhou, GuangDong Province

China, 510630

Phone:?86-20-85252276

E-mail: wanggy3@126.com, wgying@mail.sysu.edu.cn